If you take Depakote throughout pregnancy for just about any health care issue, your child is at risk for serious start defects that influence the brain and spinal wire (such as spina bifida or neural tube defects). These defects can start off in the primary thirty day period, even before you know you will be Expecting.
extreme multiorgan reactions. Treatment with DEPAKOTE may possibly cause critical multiorgan reactions that may be lifetime-threatening or may bring about Dying.
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As a result, no dosage adjustment appears to become required in individuals with renal failure. Protein binding in these patients is significantly lessened; Consequently, monitoring complete concentrations may be deceptive.
All Ladies of childbearing age (including ladies from the start of puberty) ought to discuss to their Health care company about employing other achievable treatments in lieu of Depakote. If the choice is get more info built to use Depakote, you need to use efficient birth control (contraception).
Your Health care supplier may well lower your dose, briefly cease, or permanently quit therapy When you have sure Unintended effects.
This document isn't going to incorporate all achievable Unintended effects and Some others may well manifest. Test with all your health practitioner for additional information regarding Unintended effects.
have or think you've got a genetic liver dilemma because of a mitochondrial disorder including Alpers-Huttenlocher syndrome.
are breastfeeding. Depakote can go into breast milk and should hurt your newborn. Check with your Health care service provider about The easiest method to feed your little one if you take Depakote.
Significant and lethal liver harm has actually been related to valproate, specially over the initial 6 months of procedure.
G.I. Irritation Sufferers who experience G.I. discomfort may perhaps take pleasure in administration of your drug with food items or by bit by bit build up the dose from an initial low amount.
The primary findings had been an increase in the incidence of subcutaneous fibrosarcomas in significant-dose male rats receiving valproate and also a dose-associated craze for benign pulmonary adenomas in male mice acquiring valproate.
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are pregnant or may possibly turn out to be Expecting. DEPAKOTE might harm your unborn child. See “2. Depakote may possibly hurt your unborn child” above To find out more.